Specialised nerve conduction studies for neurogenic TOS — including medial antebrachial cutaneous studies. Dr Ron Granot, FRACP, Bondi Junction.
Book Your Test NowThe thoracic outlet is the narrow space between the neck and the arm where nerves of the brachial plexus and the subclavian blood vessels pass between the collarbone and first rib. When something in this space compresses these structures — most often the lower trunk of the brachial plexus (the C8 and T1 nerve roots) — the result is neurogenic thoracic outlet syndrome (TOS).
Numbness or pins and needles along the inner forearm and the little finger side of the hand (C8-T1 dermatomes).
Difficulty with fine motor tasks — opening jars, turning keys, buttons. Weak thumb opposition and finger spread.
Hollowing of the thenar eminence (base of thumb) — the classical sign of advanced true neurogenic TOS. May be subtle early on.
Symptoms worse with overhead activity (reaching, hanging out washing, hair brushing) and with carrying heavy loads.
Deep aching pain in the shoulder, arm or hand, often poorly localised. Sometimes worse at night.
Hand swelling, colour changes, or coldness suggest vascular TOS — a separate problem from neurogenic TOS, evaluated by vascular surgery and imaging.
TOS symptoms overlap significantly with several more common conditions. NCS distinguishes them.
| Condition | Distinguishing features | NCS signature |
|---|---|---|
| Neurogenic TOS | Lower trunk (C8-T1) pattern. Thenar wasting. Symptoms with overhead activity. | Low ulnar SNAP, low MABC SNAP, low median CMAP. EMG denervation in APB, FDI, opponens. |
| Ulnar neuropathy at elbow | Numbness in little + ring fingers only. Elbow flexion worsens. Tinel's sign at cubital tunnel. | Slowing across the elbow. Spared MABC SNAP. Spared median. |
| Carpal tunnel syndrome | Thumb, index, middle finger numbness. Nocturnal symptoms. | Median sensory and motor slowing across wrist. Normal ulnar. |
| C8 radiculopathy | Neck pain often present. Pain extends from neck down arm. | Normal SNAPs (lesion is preganglionic). EMG denervation in C8 muscles including paraspinal muscles. |
| Pancoast tumour | Severe pain, weight loss, Horner's syndrome. Red flag. | Similar to TOS but with rapid progression. Chest imaging mandatory. |
Routine nerve conduction studies often miss neurogenic TOS because the most sensitive markers — particularly the medial antebrachial cutaneous nerve sensory study — are not routinely included. A targeted TOS protocol assesses:
Sensory response from the ulnar nerve at the wrist. Reduced in TOS because the lesion is post-ganglionic.
Medial antebrachial cutaneous nerve — the most sensitive single test. Reduced or absent in true neurogenic TOS.
Compound muscle action potential from APB (median-innervated, but C8/T1 root supply). Reduced amplitude in advanced TOS.
Motor response from first dorsal interosseous and ADM muscles.
Sampling of APB (median), FDI (ulnar) and opponens pollicis — both median and ulnar innervated thenar muscles confirms a lower brachial plexus lesion.
Same studies performed on the asymptomatic side for direct comparison — small side-to-side differences can be diagnostically meaningful.
Dr Granot reviews the pattern of symptoms — what makes them worse, the distribution of numbness — and examines for thenar wasting, weakness, and provocative manoeuvres (Roos, Adson) understanding their limitations.
Routine median and ulnar studies plus the targeted TOS battery — including the MABC sensory study that distinguishes TOS from compressive ulnar neuropathy.
Sampling of both median and ulnar thenar muscles to confirm a lower brachial plexus pattern. Cervical paraspinal muscles to exclude C8 radiculopathy.
Side-to-side comparison with the asymptomatic arm. Findings discussed immediately. Formal report and recommendations for further imaging or specialist referral as appropriate.
Same-day results • Specialised TOS protocol • Medial antebrachial cutaneous studies included
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